Telaprevir-Related Dermatitis
نویسندگان
چکیده
منابع مشابه
Telaprevir-related dermatitis.
OBJECTIVE To evaluate the incidence, type, and severity of telaprevir-associated skin reactions. DESIGN Three dermatologists assessed available information including photographs, biopsy results, and clinical summaries of all cases with skin eruptions reported as moderate or severe during the telaprevir clinical development program. For cases from placebo-controlled trials, they were masked to...
متن کاملManagement of refractory telaprevir-induced dermatitis using oral corticosteroids.
We present a series of 12 patients with telaprevir-induced skin toxicity. Some patients presented eczematous lesion, while others presented nonscaling macular lesions that became more purpuric in the lower limbs. Seven of the 12 patients had skin lesions affecting more than 50% of the body surface area, but none had systemic manifestations. Oral corticosteroids, prescribed in 7 patients, produc...
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Telaprevir (LY 570310; LY-570310; LY570310; MP 424; MP-424; VX 950; VX-950) is an orally administered peptidomimetic inhibitor of the hepatitis C virus (HCV) protease NS3/4A. It is being developed by Vertex Pharmaceuticals and its licensees for the treatment of HCV infections and has recently been submitted to the US FDA for approval. As the first ever HCV protease inhibitor in phase III develo...
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BACKGROUND Positive patch tests to balsam of Peru (BOP) or fragrance mix (FM) suggest the possibility of systemic contact dermatitis from balsam-related foods and spices. OBJECTIVE This was a retrospective study to determine whether avoidance of balsam-related foods results in an improvement of dermatitis in these patients. METHODS A review of the records of all patients seen from July 1 to...
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BACKGROUND In patients with chronic hepatitis C, triple drug regimens containing a protease inhibitor, peginterferon and ribavirin were found to significantly increase sustained virologic response rates compared to dual drug regimen containing pegylated interferon and ribavirin, especially in genotype 1. OBJECTIVES In Turkey, telaprevir has been used since March 2013. We aimed to evaluate res...
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ژورنال
عنوان ژورنال: JAMA Dermatology
سال: 2013
ISSN: 2168-6068
DOI: 10.1001/jamadermatol.2013.938